Pheochromocytoma (PHEO)
Nationwide Cohort study on the development of diagnosis and treatment of pheochromocytoma in Japan (PHEO-J)
・Principle investigator: Mitsuhide Naruse
・Organization:
Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
Aim
The aim of the study is to establish disease registry for elucidation of the effects of treatment and prognosis and to establish the early diagnostic methods with biochemical and histopathological markers
Subjects
Inclusion criteria:
1. Patients with pheochromocytoma who visited outpatient clinics and hospitals during April 1,
2008 to March 31, 2012
2. Age: more than 20 years of age
3. Gender: male and female
Exclusion criteria
1. Patients not visited during the specified period
2. Patients treated at the outpatients clinics and hospitals other than those specified
3. Patients who do not full-fill the diagnostic criteria
Methods
Study design: Observational, multi-center study
Target sample size: 2,500 cases
End point
Primary outcomes
1. Elucidation of the therapeutic effects and prognosis by establishing disease registry
2. Establishment of the early diagnostic method by central analysis of histopathological
markers Secondary outcome
3.Improvement of the prognosis of pheochromocytoma
Research period
1. Case recruitment: April, 2010-March, 2013
2. Follow-up: April, 2011-March, 2014
3. Secondary use in the subsequent research: Succeeded to ACPA-J (PHEO-J2)
from March, 2016
Schedule of evaluation
| VISIT | Registration | 1 year |
2 yrs |
|---|---|---|---|
| Informed consent | ● | ||
| Basic information | ● | ||
| Information at the 1st diagnosis | ● | ||
| Diagnosis | ● | ● | ● |
| Function tests | ● | ● | ● |
| Imaging tents | ● | ● | ● |
| Pathological findings | ● | ||
| Cure | ● | ● | ● |
| Out come | ● | ● | ● |