Pheochromocytoma (PHEO)

Nationwide Cohort study on the development of diagnosis and treatment of pheochromocytoma in Japan (PHEO-J)

 ・Principle investigator: Mitsuhide Naruse


    Clinical Research Institute, Kyoto Medical Center, National Hospital Organization


The aim of the study is to establish disease registry for elucidation of the effects of treatment and prognosis and to establish the early diagnostic methods with biochemical and histopathological markers


Inclusion criteria:

 1. Patients with pheochromocytoma who visited outpatient clinics and hospitals during April 1,

     2008 to March 31, 2012

 2. Age: more than 20 years of age

 3. Gender: male and female

Exclusion criteria

   1. Patients not visited during the specified period

   2. Patients treated at the outpatients clinics and hospitals other than those specified

   3. Patients who do not full-fill the diagnostic criteria



Study design: Observational, multi-center study

Target sample size: 2,500 cases


End point

Primary outcomes

  1. Elucidation of the therapeutic effects and prognosis by establishing disease registry

  2. Establishment of the early diagnostic method by central analysis of histopathological

      markers Secondary outcome

  3.Improvement of the prognosis of pheochromocytoma

Research period

 1. Case recruitment: April, 2010-March, 2013

 2. Follow-up: April, 2011-March, 2014

 3. Secondary use in the subsequent research: Succeeded to ACPA-J (PHEO-J2)

      from March, 2016


Schedule of evaluation

VISIT Registration    1 year  

  2 yrs   

Informed consent
Basic information
Information at the 1st diagnosis
Function tests
Imaging tents
Pathological findings
Out come
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